Diet & Lifestyle Study - for survival

Many patients seek advice about the influence of diet and lifestyle on breast cancer, but there is little proven research on their effect on recurrence, spread and long-term survival. Meanwhile more than 13,000 people in the UK die each year of the disease.

World class

Against Breast Cancer's Diet and Lifestyle Study (DietCompLyf) is a multi-centre clinical study investigating the diet and lifestyle, complementary and alternative treatments they may use.

It specifically focuses on the effects of naturally-occurring plant chemicals called phytoestrogens on breast cancer progression because of their oestrogen-mimicking potential. This is the largest study in the world examining this aspect of breast cancer survival and was adopted by the UK National Clinical Research Network in 2005.

The trial now involves more than 2,700 patients in 55 UK hospitals and we're confident of reaching our target of 3,000 patients by the end of 2010. Our researchers can then examine information from the full group over a five-year period.

Some of our aims

We aim to investigate how the following affect the secondary spread of breast cancer and long-term survival:

  • phytoestrogens -- a compound mimicking the hormone oestrogen that stimulates growth in 75% of breast cancers
  • diet, exercise and lifestyle
  • dietary patterns
  • food supplements
  • complementary and alternative therapies
  • levels of various dietary chemicals in the blood.

Inclusion criteria for participants

  • under 75
  • invasive primary breast cancer
  • approximately one year after diagnosis and completion of chemotherapy and/or radiotherapy

What we do

On recruitment, specialist hospital nurses collect blood and urine samples and ask patients to complete four types of questionnaire and update annually over the next four years. Further data is gathered from medical records.

  • Lifestyle questionnaire This is designed to capture a range of information including: socio-demographic data; medical history; physical activity before and after diagnosis; and use of antibiotics, alcohol, cigarettes, complementary and alternative therapies.
  • General health questionnaire A brief quality-of-life questionnaire to assess levels of anxiety and stress.
  • Food frequency questionnaire A record of how often participants eat and drink. It includes 131 key food items from which to calculate average annual intake and identify any nutritional changes over the five years of the study. We also collect information on food preparation and use of dietary supplements.
  • 7-day food diary This is used twice during the duration of the study

Cambridge collaboration

The UK version of the 7-day food diary and food frequency questionnaire was designed by the University of Cambridge in collaboration with the MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival, nutritional data is produced from the questionnaires by specialist software, and is interpreted by our team in the context of the study.

Latest news

Although we can't draw any conclusions on the effects of diet and lifestyle on breast cancer spread until we've studied all the women over the full course of the study, it's very interesting to see how many have actively made changes a year after diagnosis.

The following are observations made when investigating women's diet before and after they were diagnosed with breast cancer:

Diet

  • Increase in fruit and vegetables; a switch to wholegrains; the choice of poultry, fish and seafood over red meat, and extra protein obtained from the bean family, soy meat substitutes and nuts.
  • Decrease in high fat foods including full-fat dairy products, chips, crisps and pizza; fewer puddings, fizzy non-diet drinks, less coffee and wine.

Supplements

  • Two-thirds of the same group took some form of dietary supplement before diagnosis
  • A few women started to take supplements after diagnosis while those already using them increased the number and type.

 

When the trial is completed, we'll publish all our findings - positive, negative and non-proven - on the link between diet and lifestyle and improved breast cancer survival. In the meantime, the blood and urine samples collected at the start of the study are a crucial resource for our biochemists in detecting biomarkers for cancer spread and vaccine development. You can find more details of this landmark clinical trial at our UCL site.

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Against Breast Cancer is a registered charity in England - Registered Charity No. 1121258

Against Breast Cancer (Trading) Limited. Company registered in England number 03478706.

A wholly owned subsidiary of Against Breast Cancer Limited. Company limited by guarantee 6310215

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