There is a need for solid, evidence-based advice on diet and lifestyle factors that reduce the risk of secondary spread occurring.
Working with researchers at the University of Westminster, our DietCompLyf study enrolled over 3,300 breast cancer patients from 56 centres across the UK, each participating from one year post-diagnosis and on active follow-up for 5 years following diagnosis.
The annual blood and urine samples and questionnaire data comprise the largest collection of its kind in the UK. This resource allows the study of dietary, lifestyle and biological differences between UK patients who develop secondary spread and those who do not.
Researchers at the University of Westminster have identified patient trends in consumption of foods between age groups, and observed that weight gain is associated with higher risk of disease but that chemotherapy can contribute to weight gain, which is important to relate to patients so that they can modify their behaviour. Researchers are currently completing work that assesses the relationship between eating foods containing molecules that mimic human oestrogen, and recurrence or spread of breast cancer.
Our DietCompLyf Study is supported by the National Cancer Research Network. Patient samples have also been shared with the Breast Cancer Association Consortium (BCAC), a forum of international investigators who are combining information from many studies to identify gene mutations that give rise to a family history of breast cancer.
The DietCompLyf study has confirmed that certain activities help reduce the risk of developing secondary breast cancer, including; a healthy diet constituting at least 5 portions of fruit and vegetables a day, regular exercise, a better quality of life with reduced stress and loneliness, moderate alcohol intake, not smoking and maintaining a healthy weight.
Genetic Predisposition to In Situ and Invasive Lobular Carcinoma of the Breast Elinor Sawyer et al. PLoS Genet. 2014 April; 10(4): e1004285
The DietCompLyf study: a prospective cohort study of breast cancer survival and phytoestrogen consumption. Swann R, Perkins KA, Velentzis LS, Ciria C, Dutton SJ, Mulligan AA, Woodside JV, Cantwell MM, Leathem AJ, Robertson CE, Dwek MV. Maturitas. 2013 Jul;75(3):232-40.
19p13.1 is a triple negative-specific breast cancer susceptibility locus Stevens KN, Fredericksen Z, Vachon CM, et al. Cancer Res (2012); 72(7)1795-1803
Genome-wide association analysis identifies three new breast cancer susceptibility loci Ghoussaini M, Fletcher O, Michailidou K, et al. Nature Genetics (2012); 44(3)312-318
Significant changes in dietary intake and supplement use after breast cancer diagnosis in a UK multicentre study. Velentzis LS, Keshtgar MR, Woodside JV, Leathem AJ, Titcomb A, Perkins KA, Mazurowska M, Anderson V, Wardell K, Cantwell MM. Breast Cancer Res Treat 2011 Jul;128(2):473-82
Lignans and breast cancer risk in pre- and post-menopausal women: meta-analyses of observational studies Velentzis LS, Cantwell MM, Cardwell C, Keshtgar MR, Leathem AJ, Woodside JV. Br J Cancer 2009 May 5;100(9):1492-8